Pharmaceutical sales for age-related macular degeneration (AMD) marketplaces were projected to be $4.9 billion in 2016, and it’s expected to reach a price of $11.5 billion in 2026, with a Compound Annual Growth Rate (CAGR) rise of 8.9%, stated by a leading data and analytics company.
According to a company report states that this growth will be driven by new therapies entering the market and a global aging society, which will lead to increasing numbers of elderly people developing AMD.
Some of the predictions made by a leading data and analytics company that the launches of three drugs for the treatment of geographic atrophy (GA), the late stage of dry age-related macular degeneration (dAMD), and three late-stage pipeline drugs for wet AMD (wAMD). In particular, the launch of drugs into the AMD market to treat dAMD will be a large driver of growth, as there are currently no prescription medications available for these patients.
Healthcare expert comments as: “We expect that with the launch of brolucizumab in the wAMD market, Novartis will offset the losses to Eylea and regain dominance in the AMD market. Once more efficacy and safety data collects and physicians become more accustomed to the use of brolucizumab, its advantage of less frequent dosing will allow it to claim an increasing share and become a first-line therapy if reimbursed.”
Key opinion leaders interviewed by GlobalData emphasized that pricing will also play a key role in the uptake of brolucizumab. Novartis’ brolucizumab is estimated to reach an epic status by 2021, and will be the highest selling drug by 2026 among all drugs launching to the AMD market, with $4.1bn in global sales.
New drugs entering the dAMD market will include two anti-complement agents: Apellis’ APL-2 and Ophthotech’s Zimura, and one neuroprotective agent, Allergan’s Brimo DDS, which together will drive an increase of the treated AMD cases, expanding the AMD market.
Further the expert added “Due to the failure of each clinical test of Phase III trials of lampalizumab for the treatment of GA, Apellis’ APL-2 emerged because the most promising GA drug once it’s positive Phase IIa results were declared. Provided that the planned Phase III trial of APL-2 for GA will confirm these results, we forecast that Apellis’ drug will reach blockbuster status within a few years of its launch, by 2025.”
Table of Contents
Table of Contents
1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2 Age-Related Macular Degeneration: Executive Summary
2.1 Significant Growth Expected in the AMD Market from 2016 to 2026
2.2 R&D and Corporate Strategies Within the AMD Market
2.3 Current Therapies for AMD Leave Abundant Unmet Needs
2.4 Opportunities Will Remain for New Entrants
2.5 Late-Stage Pipeline Drugs Entering the AMD Market Will Be a Key Driver of Growth
2.6 What Do Physicians Think?
3 Introduction
3.1 Catalyst
3.2 Related Reports
3.3 Upcoming Related Reports
4 Disease Overview
4.1 Etiology and Pathophysiology
4.1.1 Overview
4.1.2 dAMD
4.1.3 wAMD
4.1.4 Genetic Targets of Interest
4.2 Classification
4.3 Symptoms
4.4 Prognosis
5 Epidemiology
5.1 Disease Background
5.2 Risk Factors and Comorbidities
5.3 Global and Historical Trends
5.4 Forecast Methodology
5.4.1 Sources Used
5.4.2 Forecast Assumptions and Methods
5.4.3 Total Prevalent Cases of AMD, Early AMD, Late AMD, Late Dry AMD, Late Wet AMD, and Large Drusen
5.4.4 Diagnosed Incident Cases of AMD, Early AMD, Late AMD, Late Dry AMD, Late Wet AMD, and Large Drusen
5.5 Epidemiological Forecast for AMD (2016–2026)
5.5.1 Total Prevalent Cases of AMD
5.5.2 Age-Specific Total Prevalent Cases of AMD
5.5.3 Sex-Specific Total Prevalent Cases of AMD
5.5.4 Total Prevalent Cases of Early AMD
5.5.5 Total Prevalent Cases of Late AMD
5.5.6 Total Prevalent Cases of Late Dry AMD
5.5.7 Total Prevalent Cases of Late Wet AMD
5.5.8 Total Prevalent Cases of Large Drusen
5.5.9 Diagnosed Incident Cases of AMD
5.5.10 Age-Specific Diagnosed Incident Cases of AMD
5.5.11 Sex-Specific Diagnosed Incident Cases of AMD
5.5.12 Diagnosed Incident Cases of Early AMD
5.5.13 Diagnosed Incident Cases of Late AMD
5.5.14 Diagnosed Incident Cases of Late Dry AMD
5.5.15 Diagnosed Incident Cases of Late Wet AMD
5.5.16 Diagnosed Incident Cases of Large Drusen
5.6 Discussion
5.6.1 Epidemiological Forecast Insight
5.6.2 Limitations of the Analysis
5.6.3 Strengths of the Analysis
6 Disease Management
6.1 Diagnosis Overview
6.2 Treatment Overview
6.2.1 Treatment Guidelines and Leading Prescribed Drugs
6.2.2 Clinical Practice
6.2.3 dAMD
6.2.4 wAMD
7 Competitive Assessment
7.1 Overview
7.2 Lucentis (Ranibizumab)
7.2.1 Overview
7.2.2 Efficacy
7.2.3 Safety
7.2.4 Forecast
7.3 Avastin (Bevacizumab)
7.3.1 Overview
7.3.2 Efficacy
7.3.3 Safety
7.3.4 SWOT Analysis
7.3.5 Forecast
7.4 Eylea (Aflibercept)
7.4.1 Overview
7.4.2 Efficacy
7.4.3 Safety
7.4.4 SWOT Analysis
7.4.5 Forecast
7.5 Macugen (Pegaptanib Sodium)
7.5.1 Overview
7.5.2 Efficacy
7.5.3 Safety
7.6 Visudyne (Verteporfin)
7.6.1 Overview
7.6.2 Efficacy
7.6.3 Safety
7.6.4 SWOT Analysis
7.6.5 Forecast
8 Unmet Needs and Opportunity Assessment
8.1 Overview
8.2 Treatment for Dry AMD
8.2.1 Unmet Need
8.2.2 Gap Analysis
8.2.3 Opportunity
8.3 Longer Acting Therapy
8.3.1 Unmet Need
8.3.2 Gap Analysis
8.3.3 Opportunity
8.4 Increased Anti-VEGF Efficacy
8.4.1 Unmet Need
8.4.2 Gap Analysis
8.4.3 Opportunity
8.5 Less Invasive Formulations
8.5.1 Unmet Need
8.5.2 Gap Analysis
8.5.3 Opportunity
8.6 Early Diagnosis and Disease Management
8.6.1 Unmet Need
8.6.2 Gap Analysis
8.6.3 Opportunity
9 Pipeline Assessment
9.1 Overview
9.2 Clinical Trial Mapping
9.2.1 Clinical Trials by Patient Population
9.3 Promising Drugs in Clinical Development
9.3.1 Brolucizumab
9.3.2 Abicipar pegol
9.3.3 OPT-302
9.3.4 APL-2
9.3.5 Zimura
9.3.6 Brimo DDS
9.4 Promising Drugs in Early-Stage Development
9.4.1 Complement Inhibitors
9.4.2 Anti-Angiogenic Agent
9.4.3 Anti-angiogenic (Topical)
9.4.4 Anti-angiogenic (Oral)
9.4.5 Anti-Fibrotic Agent
9.4.6 Stem Cell Therapy
9.5 Other Drugs in Development
9.6 Biosimilars
10 Current and Future Players
10.1 Overview
10.2 Trends in Corporate Strategy
10.3 Roche/Genentech
10.3.1 Overview
10.3.2 Portfolio Assessment
10.4 Novartis/Alcon
10.4.1 Overview
10.4.2 Portfolio Assessment
10.5 Regeneron
10.5.1 Overview
10.5.2 Portfolio Assessment
10.6 Bayer
10.6.1 Overview
10.6.2 Portfolio Assessment
10.7 Valeant
10.7.1 Overview
10.7.2 Portfolio Assessment
10.8 Allergan
10.8.1 Overview
10.8.2 Portfolio Assessment
10.9 Ohr Pharmaceutical
10.9.1 Overview
10.9.2 Portfolio Assessment
10.10 Apellis
10.10.1 Overview
10.10.2 Portfolio Assessment
10.11 Ophthotech
10.11.1 Overview
10.11.2 Portfolio Assessment
10.12 Opthea
10.12.1 Overview
10.12.2 Portfolio Assessment
11 Market Outlook
11.1 Global Markets
11.1.1 Forecast
11.1.2 Drivers and Barriers – Global Issues
11.2 US
11.2.1 Forecast
11.2.2 Key Events
11.2.3 Drivers and Barriers
11.3 5EU
11.3.1 Forecast
11.3.2 Key Events
11.3.3 Drivers and Barriers
11.4 Japan
11.4.1 Forecast
11.4.2 Key Events
11.4.3 Drivers and Barriers
12 Appendix
12.1 Bibliography
12.2 Abbreviations
12.3 Methodology
12.3.1 Forecasting Methodology
12.3.2 Diagnosed Patients
12.3.3 Percent Drug-Treated Patients
12.3.4 Drugs Included in Each Therapeutic Class
12.3.5 General Pricing Assumptions
12.3.6 Individual Drug Assumptions
12.3.7 Generic Erosion
12.3.8 Pricing of Pipeline Agents
12.4 Primary Research – KOLs Interviewed for This Report
12.5 Primary Research – Prescriber Survey
12.6 About the Authors
12.6.1 Analyst
12.6.2 Therapy Area Director
12.6.3 Epidemiologist
12.6.4 Managing Epidemiologist
12.6.5 Global Director of Therapy Analysis and Epidemiology
12.6.6 Global Head and EVP of Healthcare Operations and Strategy
12.7 About GlobalData
12.8 Contact Us
12.9 Disclaimer
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